Recent reports in Science and Medicine for April 2005
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Some may require prior registration. Check-in and view frequently to avoid missing great news items. I welcome any suggested articles. (email link). "§" indicates
a recommended article.
Weekend
Reading - Basic Science and general interest articles
- FDA Approvals: [Medscape]
- Hyzaar, (losartan potassium plus
hydrochlorothiazide), allowing its use to reduce the risk of stroke
in patients with hypertension (HTN) and left ventricular hypertrophy
(LVH). There is evidence, however, that this benefit does not apply
to black patients.
- Panzem, (2-methoxyestradiol capsules
- 2ME2) approved as orphan drug indication for use in the treatment
of ovarian cancer.
- Decapinol oral rinse for the treatment
of gingivitis in patients aged 12 years and older in whom routine
oral hygiene is not adequate to prevent the inflammatory disease.
It is intended for use in conjunction with normal brushing and
flossing.
- Prion hypothesis proven? [The
Scientist review from Cell]
- MedWatch:
- Betaseron (interferon
beta-1b) post-marketing safety surveillance reports of serious hepatic
injury including autoimmune hepatitis and severe liver damage leading
to hepatic failure and transplant. Liver function testing is recommended
at regular intervals.
- N. A..S. Panel Proposes Guidelines for Stem-Cell Research [Medscape,
News report]
- JAMA Vol.
293 No. 16, pp. 1949-2054, April 27, 2005
- Lower Cancer Incidence in Amsterdam-I Criteria
Families Without Mismatch Repair Deficiency: Familial Colorectal
Cancer Type X. JAMA.
2005;293:1979-1985.
- § Accuracy
of Revised Bethesda Guidelines, Microsatellite Instability, and
Immunohistochemistry for the Identification of Patients With Hereditary
Nonpolyposis Colorectal Cancer. JAMA.
2005;293:1986-1994.
- § Influence
of Patients’ Requests for Direct-to-Consumer Advertised Antidepressants:
A Randomized Controlled Trial. JAMA.
2005;293:1995-2002. [Medscape]
- Neuroprotective and Anti–Human Immunodeficiency
Virus Activity of Minocycline. JAMA.
2005;293:2003-2011.
- Reviews: Clinical Validity of a Negative Computed
Tomography Scan in Patients With Suspected Pulmonary Embolism:
A Systematic Review. JAMA.
2005;293:2012-2017.
- Editorials: Progress in Genetic Testing, Classification,
and Identification of Lynch Syndrome. JAMA.
2005;293:2028-2030.
- § Editorials:
Direct-to-Consumer Advertising: A Haphazard Approach to Health
Promotion. JAMA.
2005;293:2030-2033. [New
Scientist]
- MMWR April 22, 2005 / 54(15);377-380 Homicide
and Suicide Rates --- National Violent Death Reporting System, Six
States, 2003
- Randomized Trial of High Loading Dose of Clopidogrel for Reduction of
Periprocedural Myocardial Infarction in Patients Undergoing Coronary Intervention:
Results From the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial
Damage during Angioplasty) Study.Circulation
2005 111: 2099 - 2106. [Medscape:
Aspirin Plus Clopidogrel May Be Better Than Clopidogrel Alone in Carotid
Stenosi]
- § New
anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin. British
Journal of Pharmacology (2005) 144, 1017-1028.
- § Dosing
With 5% Imiquimod Cream 3 Times per Week for the Treatment of Actinic Keratosis
Results of Two Phase 3, Randomized, Double-blind, Parallel-Group, Vehicle-Controlled
Trials. Arch
Dermatol. 2005;141:467-473.[Medscape review]
- The effect of high altitude commercial air travel on oxygen saturation. Anaesthesia
2005; 60: 458. (limited access)[Eurekalert:
54 per cent of air passengers experience significant reduction in oxygen
levels]
- § Neurocognitive
complications after coronary artery bypass surgery. Annals
of Neurology 2005; 57: 615 - 621. [Eurekalert]
- § Development
of a humanized monoclonal antibody with therapeutic potential against West
Nile virus. Nature
Medicine Published online: 24 April 2005. [News
report]
- Simultaneous carotid endarterectomy and coronary artery bypass surgery
in Canada. Neurology
2005 64: 1435-1437. [Medscape]
- Lancet
Volume 365, Number 9468 16 April 2005
- § Effects
of the cannabinoid-1 receptor blocker rimonabant on weight reduction
and cardiovascular risk factors in overweight patients: 1-year
experience from the RIO-Europe study [Summary]
- Prevalence of the metabolic syndrome and overweight
among adults in China [Summary]
- Paraneoplastic stiff-person syndrome: passive transfer
to rats by means of IgG antibodies to amphiphysin [Summary]
- Inadequate anaesthesia in lethal injection for
execution [ Full
Text]
- The metabolic syndrome [Summary]
- Epidemiology 2: Compared to what? Finding controls
for case-control studies [Summary]
- Time and chance: the stochastic nature of disease
causation [Summary]
- Lancet Volume 365, Number 9469 23 April 2005
- Supervised versus unsupervised intake of six-dose
artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium
falciparum malaria in Mbarara, Uganda: a randomised trial. [Full
Text]
- Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine,
amodiaquine+artesunate, and artemether-lumefantrine for outpatient
treatment of malaria in Tanzanian children: a four-arm randomised
effectiveness trial [Full
Text] [News
report]
- Intermittent preventive antimalarial treatment
for Tanzanian infants: follow-up to age 2 years of a randomised,
placebo-controlled trial [Full
Text]
- Aortic wall thickness in newborns with intrauterine
growth restriction [Summary]
- Seminar: Malaria. [Full
Text]
- Personal Account: Do as I say, not as I do [ Full
Text]
- Epidemiology 3: Refining clinical diagnosis with
likelihood ratios [Summary]
- Public Health: Malaria control in Afghanistan:
progress and challenges [Full
Text]
- Uses of Error:"I think she's just crazy" [Summary]
- Case Report: Chest pain and fleeting neurological
signs [Summary]
- New England Journal of Medicine Volume
352 April 21, 2005 Number 16
- BMJ 16
April 2005 (Vol 330, No 7496)
- § Role
of multivitamins and mineral supplements in preventing infections
in elderly people: systematic review and meta-analysis of randomised
controlled trials. BMJ 2005;330:871.
- § Quetiapine
and rivastigmine and cognitive decline in Alzheimer's disease:
randomised double blind placebo controlled trial. BMJ 2005;330:874
- A feasibility study of signed consent for the
collection of patient identifiable information for a national paediatric
clinical audit database. BMJ 2005;330:877-879.
- Operative delivery and postnatal depression: a
cohort study. BMJ 2005;330:879.
- " Frequent flier" patients. BMJ 2005;330:869
- Shared help seeking behaviour within families:
a retrospective cohort study. BMJ 2005;330:882,.
- The patient's journey: multiple sclerosis. BMJ 2005;330:885-888
- Interactive case report: Postoperative hypoxia
in a woman with Down's syndrome: case progression. BMJ 2005;330:888.
- Lesson of the week: A life threatening complication
after colonoscopy. BMJ 2005;330:889-890.
- § ABC
of adolescence: Suicide and deliberate self harm in young people. BMJ 2005;330:891-894
- § Reader's
guide to critical appraisal of cohort studies: 1. Role and design. BMJ 2005;330:895-897.
- Improving diet and physical activity: 12 lessons
from controlling tobacco smoking. BMJ 2005;330:898-900
- Young people's health: the need for action. BMJ 2005;330:901-903
- BMJ 23
April 2005 (Vol 330, No 7497)
- Was Rodney Ledward a statistical outlier? Retrospective
analysis using routine hospital data to identify gynaecologists'
performance, BMJ 2005;330:929.
- Incidence and risk factors for non-alcoholic steatohepatitis:
prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention
trial. BMJ 2005;330:932.
- Model of outcomes of screening mammography: information
to support informed choices. BMJ 2005;330:936.
- Trends in number of hysterectomies performed in
England for menorrhagia: examination of health episode statistics,
1989 to 2002-3. BMJ 2005;330:938-939.
- Coverage and uptake of systematic postal screening
for genital Chlamydia trachomatis and prevalence of infection in
the United Kingdom general population: cross sectional study. BMJ 2005;330:940.
- Breast reconstruction. BMJ 2005;330:943-948.
- Lesson of the week: In vitro and in vivo haemolysis
and potassium measurement. BMJ 2005;330:949.
- ABC of adolescence: Eating disorders and weight
problems. BMJ 2005;330:950-953.
- Current controversies: Who needs health care—the
well or the sick? BMJ 2005;330:954-956.
- Principles for international registration of protocol
information and results from human trials of health related interventions:
Ottawa statement (part 1) BMJ 2005;330:956-958.
- Commentary: Why industry should register and disclose
results of clinical studies—perspective of a recovering academic. BMJ 2005;330:959.
- Reader's guide to critical appraisal of cohort
studies: 2. Assessing potential for confounding. BMJ 2005;330:960-962.
- Early Release: Day care in infancy and risk of
childhood acute lymphoblastic leukaemia: findings from UK case-control
study. BMJ,
(published 22 April 2005) [Eurekalert]
- Early Release: Metformin and reduced risk of cancer
in diabetic patients. BMJ,
(published 22 April 2005) [Eurekalert]
Weekend
Reading - Basic Science and general interest articles
- FDA issues a Public Health Advisory for antipsychotic drugs used for
treatment of behavioral disorders in elderly patients.
- FDA
Talk Paper.
- Public
Health Advisory.
- MedWatch:
Atypical Antipsychotic Drugs - New safety information concerning
an unapproved, “off-label” use . FDA has determined
that the treatment of behavioral disorders in elderly patients
with dementia with atypical (second generation) antipsychotic
medications is associated with increased mortality. Clinical
studies of these drugs in this population have shown a higher
death rate associated with their use compared to patients receiving
a placebo.
- FDA Approvals: [Medscape
review]
- Nexium IV ( intravenous formulation
of esomeprazole magnesium ) for the short-term (up to 10 days)
treatment of gastroesophageal reflux disease (GERD) in patients
with a history of erosive esophagitis who are unable to swallow
capsules.
- Zofran (ondasetron) expanded indication
allowing its use in infants aged one month and older for the prevention
of postoperative nausea and vomiting, and in infants aged six months
and older for the prevention of chemotherapy-induced nausea and
vomiting.
- Xibrom (bromfenac ophthalmic solution)
for the treatment of postoperative ocular inflammation in patients
who have undergone cataract extraction
- Decapinol Oral
Rinse treats gingivitis by reducing the number of bacteria that
attach to tooth surfaces and cause dental plaque. Decapinol is
approved for use in persons 12 years of age or older when routine
oral hygiene is not adequate to prevent gingivitis. Decapinol is
not recommended for use by pregnant women..
- FDA Approvals [Medscape]
- Restore (rechargeable neurostimulation
system) to aid in the management of chronic intractable pain of the
trunk and/or limbs, including unilateral or bilateral pain associated
with failed back syndrome, postlaminectomy pain, unsuccessful disc
surgery, degenerative nerve disorders, and other conditions.
- DuraSeal (dural sealant system) as
an adjunct to sutured dural repair during cranial surgery to achieve
watertight closure. Leakage of cerebrospinal fluid (CSF) can lead to
serious complications such as severe headaches, infection, and meningitis.
- AcrySof ReSTOR (intraocular lens)
for primary implantation for the visual correction of aphakia secondary
to cataract removal in adult patients with and without presbyopia who
desire near, intermediate, and distance vision with decreased reliance
on glasses.
- MEDWATCH:
- Trileptal (oxcarbazepine)
revisioned prescribing information- serious dermatological reactions,
including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis
(TEN) that have been reported in both children and adults in association
with Trileptal use. Multi-organ hypersensitivity reactions have
been reported in association with Trileptal use.
- FDA Safety Labeling Changes: [Medscape review]
- Viramune (nevirapine)- risk of potentially
life-threatening hepatotoxicity and skin reactions associated with
their use.
- Copegus (ribavirin) -us of ribavirin
plus peginterferon alfa-2a combination therapy is contraindicated
in patients with chronic hepatitis C virus (HCV) infection, with
or without HIV coinfection, who demonstrate hepatic decompensation
(Child-Pugh score > 6; class B and C) prior to or during treatment.
Its use is also contraindicated in patients with autoimmune hepatitis.)
- Malarone (atovaquone plus proguanil)
- rare cases of anaphylaxis associated with their use.
- Competition in health care may not result in better quality. [Eurekalert report
from current (April) issue of the journal, Medical Care (subscription only).]
- Hospital Computers May Be Reservoir for Transmission of Resistant Bacteria.
[Medscape]
- Dr. Maurice R. Hilleman, a microbiologist who developed vaccines for
mumps, measles, chickenpox, pneumonia, meningitis and other diseases, saving
tens of millions of lives, diedApril 11, 2005. He was 85. Dr. Hilleman
developed 8 of the 14 vaccines routinely recommended: measles, mumps, hepatitis
A, hepatitis B, chickenpox, meningitis, pneumonia and Haemophilus influenzae
bacteria. He also developed the first generation of a vaccine against rubella
or German measles. The vaccines have virtually vanquished many of the once
common childhood diseases in developed countries.Dr. Hilleman probably
saved more lives than any other scientist in the 20th century, said two
medical leaders, Dr. Anthony S. Fauci, director of the National Institute
of Allergy and Infectious Diseases,and Dr. Paul A. Offit, chief of infectious
diseases at Children's Hospital in Philadelphia. [ NYTimes
Obituary] (bio)
[Nature
bio]
- Positive affect and health-related neuroendocrine, cardiovascular, and
inflammatory processes. PNAS
published April 19, 2005, 10.1073 [News
report: Happier is healthier]
- Statin Use Before and After an Ischemic Event Has Better Outcomes Medscape report
from the 57th annual meeting of the American Academy of Neurology.
- Many US Seniors Won't Take Prescribed Drugs -- Study [Medscape]
- Study finds possible mechanism for link between sleep disturbances and
metabolic syndrome. [Eurekalert report
from Science].
- Annals of Internal Medicine 19 April 2005 Volume 142 Issue 8
- Clinical and Economic Implications of the Multicenter Automatic Defibrillator Implantation Trial-II. Al-Khatib, Anstrom, Eisenstein, Peterson, and others.
- Cost-Effectiveness of Defending against Bioterrorism: A Comparison of Vaccination and Antibiotic Prophylaxis against
Anthrax. Fowler, Sanders, Bravata, Nouri, Gastwirth, and others.
- § The
Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized
Trial. Orchard, Temprosa, Goldberg,Haffner,Ratner, Marcovina.
- Brief Communication: High Incidence of Venous Thrombotic Events amongPatients with Wegener Granulomatosis: The
Wegener's Clinical Occurrence of Thrombosis(WeCLOT) Study. Merkel,
Lo, Holbrook, Tibbs, Allen, Davis, and others.
- § Ambiguity
and Workarounds as Contributors to Medical Error. Spear
andSchmidhofer
- The Ethics of Deactivating Implanted Cardioverter Defibrillators.
Berger
- § REVIEWS:
Meta-Analysis: Computed Tomographic Colonography.Mulhall,
Veerappan, and Jackson.
- Meta-Analysis: Acupuncture for Low Back Pain. Manheimer,
White, Berman, Forys, and Ernst.
- EDITORIALS: Preventing Sudden Cardiac Death: Can We Afford the Benefit?
Hull
- Being Prepared: Modeling the Response to an Anthrax
Attack.Webb
- Can Computed Tomographic Colonography Become a "Good" Screening
Test? Imperiale
- Primary Care, Generalism, Public Good: Déjà vu?
Again! Larson,
Roberts, and Grumbach
- ON BEING A DOCTOR: Spot(s) Robins
- MEDICAL WRITINGS: WORDS THAT MAKE A DIFFERENCE.
On Saying Goodbye: Acknowledging the End of the Patient–Physician
Relationship with Patients Who Are Near Death. Back,
Arnold, Tulsky, Baile, and Fryer-Edwards
- SUPPLEMENT: Supplement: The Future of Generalism
in Medicine. Editors: Larson, Roberts, Grumbach, and Laine
- Circulation Volume 111, Issue 15; April 19, 2005
- § Interaction
of Body Mass Index and Framingham Risk Score in Predicting Incident
Coronary Disease in Families. Circulation
2005 111: 1871 - 1876,
- Progression of Subclinical Coronary Atherosclerosis:
Does Obesity Make a Difference? Circulation
2005 111: 1877 - 1882,
- § Enlarged
Waist Combined With Elevated Triglycerides Is a Strong Predictor of Accelerated Atherogenesis and Related Cardiovascular Mortality
in Postmenopausal Women. Circulation 2005 111: 1883 - 1890,
- § Association
of Body Mass Index and Obesity Measured in Early Childhood With Risk of Coronary Heart Disease and Stroke in Middle Age: Findings
From the Aberdeen Children of the 1950s Prospective Cohort Study. Circulation
2005 111: 1891 - 1896,
- Weight Gain in the First Week of Life and Overweight in Adulthood: A Cohort Study of European American Subjects Fed
Infant Formula. Circulation 2005 111: 1897 - 1903. [NEWS REPORT]
- Fatness Is a Better Predictor of Cardiovascular Disease Risk Factor Profile Than Aerobic Fitness in Healthy Men.
Circulation 2005 111: 1904 - 1914.
- Diet and Exercise Training Restore Blood Pressure and Vasodilatory Responses During Physiological Maneuvers in Obese
Children. Circulation 2005 111: 1915 - 1923.
- Body Build and Risk of Cardiovascular Events in Hypertension and Left Ventricular Hypertrophy: The LIFE (Losartan
Intervention For Endpoint reduction in hypertension) Study. Circulation
2005 111: 1924 - 1931.
- Origins of the "Black/White" Difference in Blood Pressure: Roles of Birth Weight, Postnatal Growth, Early
Blood Pressure, and Adolescent Body Size: The Bogalusa Heart Study. Circulation
2005 111: 1932 - 1937.
- Genotype Associated With Environmentally Induced Breast Cancer Women with a N-acetyltransferase 2 (NAT2) slow acetylator genotype have an increased
risk of breast cancer, according to a report in the April 20th issue of the Int
J Cancer 2005;114:579-584.. [Medscape]
- JAMA. 2005;293:1829.
- New England Journal of Medicine Volume 352 April 14, 2005 Number 15
- Cardiac Autonomic Changes Associated With Fish Oil vs Soy Oil Supplementation in the Elderly.
Chest 2005 127: 1102-1107.
- JAMA Vol. 293 No. 14, pp. 1701-E4, April 13, 2005
- Preferences of Women Evaluating Risks of Tamoxifen (POWER) study of preferences
for tamoxifen for breast cancer risk reduction (p NA). Cancer
early online: 11 Apr 2005
DOI: 10.1002/cncr.20981 [Medscape]
Weekend
Reading - Basic Science and general interest articles
- FDA Approvals: [Medscape
review]
- Nexium IV ( intravenous
formulation of esomeprazole magnesium ) for the short-term
(up to 10 days) treatment of gastroesophageal reflux
disease (GERD) in patients with a history of erosive
esophagitis who are unable to swallow capsules.
- Zofran (ondasetron)
expanded indication allowing its use in infants aged
one month and older for the prevention of postoperative
nausea and vomiting, and in infants aged six months and
older for the prevention of chemotherapy-induced nausea
and vomiting.
- Xibrom (bromfenac ophthalmic
solution) for the treatment of postoperative ocular inflammation
in patients who have undergone cataract extraction.
- FDA issues a Public Health Advisory for antipsychotic drugs used for
treatment of behavioral disorders in elderly patients.
- FDA
Talk Paper.
- Public
Health Advisory.
- MedWatch:
Atypical Antipsychotic Drugs - New safety information concerning
an unapproved, “off-label” use . FDA has determined
that the treatment of behavioral disorders in elderly patients
with dementia with atypical (second generation) antipsychotic
medications is associated with increased mortality. Clinical
studies of these drugs in this population have shown a higher
death rate associated with their use compared to patients receiving
a placebo.
- Competition in health care may not result in better quality. [Eurekalert report
from current (April) issue of the journal, Medical Care (subscription only).]
- Hospital Computers May Be Reservoir for Transmission of Resistant Bacteria.
[Medscape]
- Dr. Maurice R. Hilleman, a microbiologist who developed vaccines for
mumps, measles, chickenpox, pneumonia, meningitis and other diseases, saving
tens of millions of lives, diedApril 11, 2005. He was 85. Dr. Hilleman
developed 8 of the 14 vaccines routinely recommended: measles, mumps, hepatitis
A, hepatitis B, chickenpox, meningitis, pneumonia and Haemophilus influenzae
bacteria. He also developed the first generation of a vaccine against rubella
or German measles. The vaccines have virtually vanquished many of the once
common childhood diseases in developed countries.Dr. Hilleman probably
saved more lives than any other scientist in the 20th century, said two
medical leaders, Dr. Anthony S. Fauci, director of the National Institute
of Allergy and Infectious Diseases,and Dr. Paul A. Offit, chief of infectious
diseases at Children's Hospital in Philadelphia. [ NYTimes
Obituary] (bio)
- Statin Use Before and After an Ischemic Event Has Better Outcomes Medscape report
from the 57th annual meeting of the American Academy of Neurology.
- Cardiac Autonomic Changes Associated With Fish Oil vs Soy Oil Supplementation
in the Elderly. Chest
2005 127: 1102-1107.
- JAMA Vol. 293 No.
14, pp. 1701-E4, April 13, 2005
- Preferences of Women Evaluating Risks of Tamoxifen (POWER) study of preferences
for tamoxifen for breast cancer risk reduction (p NA). Cancer
early online: 11 Apr 2005
DOI: 10.1002/cncr.20981 [Medscape]
- Renalase is a novel, soluble monoamine oxidase that regulates cardiac
function and blood pressure. JCI
2005 Online April 7, 2005. [Eurekalert]
- The N-terminal Pro-BNP Investigation of Dyspnea in the Emergency department
(PRIDE) study. Am J Cardio 2005; 95: 948-954 (via CardioSource) [Eurekalert:
Blood test can accurately diagnose heart failure in emergency patients]
- Early Differential Diagnosis of Multiple Sclerosis Using a New Oligoclonal
Band Test. Arch
Neurol. 2005;62:574-577. [Medscape]
- BMJ Early release: Open access and openly accessible: a study of scientific
publications shared via the internet. BMJ,
doi:10.1136/bmj.38422.611736.E0.
- Archives of Internal Medicine . 2005;Volume
165:718.
- Acute Alcohol Consumption Disrupts the Hormonal Milieu of Lactating
Women. J
Clin Endo Met.2005;90: 1979. [Eurekalert Eurekalert 2
reports]
- Early and late mortality after myocardial infarction in men and women:
prospective observational study. Heart
2005;91:305-307.
- The Lancet Volume 365, Number 9467 09 April 2005
- Prevalence of serious mental disorder in 7000
refugees resettled in western countries: a systematic review [Full
Text]
- Medical end-of-life decisions in neonates and infants
in Flanders [Summary]
- Re-emergence of Chlamydia trachomatis infection
after mass antibiotic treatment of a trachoma-endemic Gambian community:
a longitudinal study [Full
Text]
- Medical end-of-life decisions made for neonates
and infants in the Netherlands, 1995-2001 [Summary]
- Seminar: Type 2 diabetes: principles of pathogenesis
and therapy [Summary]
- Personal Account: Type 2 diabetes [Summary]
- Series: Epidemiology 1: Sample size calculations
in randomised trials: mandatory and mystical [Summary]
- BMJ 9
April 2005 (Vol 330, No 7495)
- Editorials: " Right to die" BMJ 2005;330:799
- Estimate of deaths attributable to passive smoking
among UK adults: database analysis. BMJ 2005;330:812,
- Impact of misclassification of in vitro fertilisation
in studies of folic acid and twinning: modelling using population
based Swedish vital records.BMJ 2005;330:815
- Utility of testing for monoclonal bands in serum
of patients with suspected osteoporosis: retrospective, cross sectional
study. BMJ 2005;330:818.
- Statin use in the secondary prevention of coronary
heart disease in primary care: cohort study and comparison of inclusion
and outcome with patients in randomised trials. BMJ 2005;330:821.
- Prophylaxis and follow-up after possible exposure
to HIV, hepatitis B virus, and hepatitis C virus outside hospital:
evaluation of policy 2000-3. BMJ 2005;330:825-829.
- Necrotising fasciitis. BMJ 2005;330:830-833.
- Interactive case report: Postoperative hypoxia
in a woman with Down's syndrome: case presentation. BMJ 2005;330:834
- ABC of adolescence: Common mental health problems. BMJ 2005;330:835-838
- Education and debate: Managing common mental health
disorders in primary care: conceptual models and evidence base. BMJ 2005;330:839-842.
- Statistics Notes: Treatment allocation by minimisation. BMJ 2005;330:843.
- 8 April 2005 online first: Modified Mediterranean diet and survival:
EPIC-elderly prospective cohort study. [Abstract]
[PDF]
- Consumption of milk and calcium in midlife and the future risk of Parkinson
disease. Neurology
2005 64: 1047-1051. [Medscape]
- A 30-minute walk is good, but a 10,000-step walk is better [News
report from April Medicine & Science
in Sports & Exercise (limited access)]
- Risk Factors for Functional Decline in Older Adults With Arthritis, Arthritis & Rheumatism:
2005; 52:4; 1274-1282.[Medscape]
- Association of Epstein-Barr Virus With Systemic Lupus Erythematosus:
Effect Modification by Race, Age, and Cytotoxic T Lymphocyte-Associated
Antigen 4 Genotype, Arthritis & Rheumatism
2005; 52:4; 1148-1159.[Eurekalert]
- New England Journal of Medicine Volume
352 Number 14 April 7, 2005
Weekend
Reading - Basic Science and general interest articles
- FDA NEWS
- FDA Safety Report: Bextra (valdecoxib):
After concluding that the overall risk versus benefit profile is
unfavorable, FDA has requested Pfizer, Inc. to voluntarily withdraw
Bextra (valdecoxib) from the market. This request is based on:
- * The lack of adequate data on the cardiovascular
safety of long-term use of Bextra, along with the increased
risk of adverse cardiovascular (CV) events in short-term
coronary artery bypass surgery (CABG) trials that FDA believes
may be relevant to chronic use.
- * Reports of serious and potentially life-threatening
skin reactions, including deaths, in patients using Bextra.
The risk of these reactions in individual patients is unpredictable,
occurring in patients with and without a prior history of
sulfa allergy, and after both short- and long-term use.
- * Lack of any demonstrated advantages for
Bextra compared with other NSAIDs.
- § FDA
News: April 7, 2005: FDA Announces Series of Changes to the
Class of Marketed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
- FDA
Public Health Advisory: FDA Announces Important Changes and
Additional Warnings for COX-2 Selective and Non-Selective
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
- Advisory:
COX-2 Selective and Non-Selective Non-Steroidal Anti-Inflammatory
Drugs (NSAIDs)
- Questions
and Answers: FDA Regulatory Actions for the COX-2 Selective
and Non-Selective Non-Steroidal Anti-inflammatory drugs (NSAIDs)
- FDA Approves Once-a-Month Osteoporosis Pill that
can be taken just once monthly in a single tablet. Oral Boniva
(ibandronate sodium) for treatment of postmenopausal osteoporosis,
manufactured by Roche and GlaxoSmithKline (GSK), has been shown
effective in improving bone density.
- FDA Approvals: Asmanex Twisthaler (mometasone
furoate) inhalation powder; DuraSeal Dural
Sealant System to Prevent Cerebrospinal Fluid Leaks After Brain
Surgery.
- FDA Safety Labeling Changes: [Medscape
report]
- Aranesp (darbepoetin alfa
injection) - increased risk of thrombotic events and mortality
associated with its use.
- Avastin (bevacizumab injection)
increased risk of arterial thromboembolic events associated
with its use.
- Intron A (interferon alfa-2b
[recombinant] injection) risk of hemolytic anemia associated
with its use in combination with ribavirin
- HHS: Hospital Compare -
A quality tool for adults, including people with Medicare
- Glowing hearts shine light on heart disease[Eurekalert report
from Nature
Medicine, CaM kinase activity may be useful for treating patients with
structural heart disease and myocardial dysfunction.
- Cellular iron: Ferroportin is the only way out. Cell
Metabolism, 2005; 1, 155-157, [ Science
Daily ]Supplementation with Conjugated Linoleic Acid for 24 Months
Is Well Tolerated by and Reduces Body Fat Mass in Healthy, Overweight
Humans. J.
Nutr. 2005 135: 778-784.
- Oral Versus Vaginal Sex Among Adolescents: Perceptions, Attitudes, and
Behavior. Pediatrics
2005; 115: 845-851.[Eurekalert]
- Phototargeting Oral Black-Pigmented Bacteria. Antimicrob
Agents Chemother. 2005 Apr;49(4):1391-6. [New
Scientist Mini 'light sabres' may battle gum disease]
- § It
Is Time to Implement Routine, Not Risk-Based, HIV Testing.Clin
Inf Dis 2005; 4:1037, [Eurekalert]
- Purpura Fulminans Due to Staphylococcus aureus. Clin
Inf Dis 2005; 4: 941. [Eurekalert]
- Improving Influenza, Pneumococcal Polysaccharide, and Hepatitis B Vaccination
Coverage Among Adults Aged <65 Years at High Risk: A Report on Recommendations
of the Task Force on Community Preventive Services. MMWR
April 1, 2005 / Vol. 54 / No. RR--5
- § Menopausal
Hormone Therapy After Breast Cancer: The Stockholm Randomized Trial. JNCI
2005; 97: 533-535.
- EDITORIAL: Progestins and Recurrence in Breast Cancer Survivors. JNCI
2005; 97: 471-472. [Medscape]
- JAMA Vol.
293 No. 13 April 6, 2005
- § Outcomes
in Hypertensive Black and Nonblack Patients Treated With Chlorthalidone,
Amlodipine, and Lisinopril. JAMA.
2005;293:1595-1608. [Medscape]
- § N-Terminal
Pro-Brain Natriuretic Peptide, C-Reactive Protein, and Urinary
Albumin Levels as Predictors of Mortality and Cardiovascular Events
in Older Adults. JAMA.
2005;293:1609-1616. [Medscape]
- § Efficacy
and Tolerability of Long-Acting Injectable Naltrexone for Alcohol
Dependence: A Randomized Controlled Trial. JAMA.
2005;293:1617-1625. [Medscape]
- Effects of Exercise and Stress Management Training
on Markers of Cardiovascular Risk in Patients With Ischemic Heart
Disease: A Randomized Controlled Trial. JAMA.
2005;293:1626-1634.
- Evaluating Iatrogenic Risk of Youth Suicide Screening
Programs: A Randomized Controlled Trial. JAMA.
2005;293:1635-1643.
- Association Between Compensation Status and Outcome
After Surgery: A Meta-analysis. JAMA.
2005;293:1644-1652.
- Clinical Review: The Clinical Sequelae of Intravascular
Hemolysis and Extracellular Plasma Hemoglobin: A Novel Mechanism
of Human Disease. JAMA.
2005;293:1653-1662.
- Editorials: Diuretics Are Color Blind. JAMA.
2005;293:1663-1666. [Eurekalert]
- Cardiovascular Risk Stratification in Older Patients:
Role of Brain Natriuretic Peptide, C-Reactive Protein, and Urinary
Albumin Levels. JAMA.
2005;293:1667-1669.
- Cholesterol targeting alters lipid raft composition and cell survival
in prostate cancer cells and xenografts. J.
Clin. Invest. 2005 115: 959-968.[Eurekalert]
- § Review:
Nonalcoholic fatty liver disease. CMAJ
2005; 172 (7). doi:10.1503/cmaj.045232.
- Prospective study of physical activity and physical function in early
old age. Am J Preventive Med 2005; 28: 245-250. (via
Science Direct)[News
report: Physical Activity in Middle Age Linked to Fitness Later]
- § Phosphodiesterase-5
Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left
Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity. Circulation
2005 111: 1601 - 1610 . [Eurekalert]
- Review: The prevalence and impact of alcohol problems in major depression:
A systematic review. AJM 2005;
118: 330-341
- Immunopathogenesis and therapy of cutaneous T cell lymphoma. J.
Clin. Invest. 2005 115: 798-812.
- The Effects of Type 1 Diabetes on Cognitive Performance: A meta-analysis. Diabetes
Care 2005 28: 726-735. [Medscape]
- Annals of Internal Medicine 5
April 2005 Volume 142 Issue 7
- The Risk for Myocardial Infarction with Cyclooxygenase-2
Inhibitors: A Population Study of Elderly Adults. Abstract
- § A
Randomized Trial of Diagnostic Strategies after Normal Proximal
Vein Ultrasonography for Suspected Deep Venous Thrombosis: D-Dimer
Testing Compared with Repeated Ultrasonography. Abstract
- Cystatin C Concentration as a Risk Factor for Heart
Failure in Older Adults. Abstract
- Duration of Platelet Dysfunction after a 7-Day
Course of Ibuprofen. Abstract [Medscape]
- Meta-Analysis: Low-Dose Dopamine Increases Urine
Output but Does Not Prevent Renal Dysfunction or Death. Abstract
- § Clinical
Guidelines Pharmacologic and Surgical Management of
Obesity in Primary Care: A Clinical Practice Guideline from the
American College of Physicians [Medscape]
- Meta-Analysis: Pharmacologic Treatment of Obesity. Abstract
- Meta-Analysis: Surgical Treatment of Obesity. Abstract
- § Ethics
Manual: Fifth Edition. The Ethics and Human Rights Committee,
American College of Physicians [Eurekalert]
- EDITORIAL:
Revisiting the Past Strengthens the Present: An Evidence-Based
Medicine Approach for the Diagnosis of Deep Venous Thrombosis
- EDITORIAL:
Cystatin C, Serum Creatinine, and Estimates of Kidney Function:
Searching for Better Measures of Kidney Function and Cardiovascular
Risk.
- § Cognitive
Therapy vs Medications in the Treatment of Moderate to Severe Depression. Arch
Gen Psychiatry. 2005;62:409-416. [News
report]
- § Prevention
of Relapse Following Cognitive Therapy vs Medications in Moderate to Severe
Depression. Arch
Gen Psychiatry. 2005;62:417-422.
- Suicide Risk in Relation to Psychiatric Hospitalization: Evidence Based
on Longitudinal Registers. Arch
Gen Psychiatry. 2005;62:427-432.
- Impact of 3-Tier Formularies on Drug Treatment of Attention-Deficit/Hyperactivity
Disorder in Children. Arch
Gen Psychiatry. 2005;62:435-441.
- Increased Caudate Dopamine D2 Receptor Availability as a Genetic Marker
for Schizophrenia. Arch
Gen Psychiatry. 2005;62:371-378.
- Antipsychotic Drug Effects on Brain Morphology in First-Episode Psychosis. Arch
Gen Psychiatry. 2005;62:361-370. [Eurekalert]
- The Efficacy of Light Therapy in the Treatment of Mood Disorders: A Review
and Meta-Analysis of the Evidence. Am
J Psychiatry 2005 162: 656-662. [Eurekalert]
- SSRI and statin use increases the risk for vasospasm after subarachnoid
hemorrhage. Neurology
2005 64: 1008-1013.[Medscape]
- BMJ 2
April 2005 (Vol 330, No 7494)
- § Screening
for abdominal aortic aneurysms: single centre randomised controlled
trial. BMJ 2005;330:750
- Identifying outcome reporting bias in randomised
trials on PubMed: review of publications and survey of authors. BMJ 2005;330:753
- Perceptions of open access publishing: interviews
with journal authors. BMJ 2005;330:756
- Commentary: Open access publishing: too much oxygen? BMJ 2005;330:759
- Effects of acupuncture and stabilising exercises
as adjunct to standard treatment in pregnant women with pelvic
girdle pain: randomised single blind controlled trial. BMJ 2005;330:761.
- § Improving
clinical practice using clinical decision support systems: a systematic
review of trials to identify features critical to success. BMJ 2005;330:765.
- Clinical review: Recent developments in bisphosphonates
for patients with metastatic breast cancer. BMJ 2005;330:769-773.
- Lesson of the week: Atypical presentation of coeliac
disease. BMJ 2005;330:773-774.
- § Lesson
of the week: Antibody negative coeliac disease presenting in elderly
people—an easily missed diagnosis. BMJ 2005;330:775-776
- ABC of adolescence: Substance misuse: alcohol,
tobacco, inhalants, and other drugs. BMJ 2005;330:777-780.
- Five pitfalls in decisions about diagnosis and
prescribing. BMJ 2005;330:781-783.
- Commentary: Can we avoid bias? BMJ 2005;330:784
- Current controversies: Surgery is the best intervention
for severe coronary artery disease. BMJ 2005;330:785-786
- US and UK health care: a special relationship?:
Moving towards true integration. BMJ 2005;330:787-788
- Early release: Role of multivitamins and mineral
supplements in preventing infections in elderly people: systematic
review and meta-analysis of randomised controlled trials. BMJ,
online/bmj 38399.495648.8F [Medscape]
- The Lancet Volume 365, Number 9466
- 02 April 2005
- § Neutrophil
gelatinase-associated lipocalin (NGAL) as a biomarker for acute
renal injury after cardiac surgery [Summary]
[Medscape]
- § Does
DOTS work in populations with drug-resistant tuberculosis? [Full
Text] [
- Ethnic variations in sexual behaviour in Great
Britain and risk of sexually transmitted infections: a probability
survey [Summary]
- § Re-emergence
of early pandemic Staphylococcus aureus as a community-acquired
meticillin-resistant clone [Summary]
- Seminar: Autonomic peripheral neuropathy [Summary]
- Rapid Review: Post-mortem MRI as an adjunct to
fetal or neonatal autopsy [Summary]
- Public Health: Promoting Arab and Israeli cooperation:
peacebuilding through health initiatives [Full
Text]
- Archives of Internal Medicine Vol.
165 No. 6, pp. 601-708, March 28, 2005
Weekend
Reading - Basic Science and general interest articles
- § FDA
:: MEDWATCH
- Trecator (ethionamide
tablets) reformulated to film-coated tablets is more rapidly absorbed,
resulting in higher peak concentrations. Patients should be monitored
and have their dosages re-titrated when switching from the sugar-coated
tablet to the film-coated tablet.
- Zometa (zoledronic
acid) revisions to the DOSAGE AND ADMINISTRATION and WARNINGS management
of patients with advanced cancer and renal impairment, whose baseline
creatinine clearance is 60 ml/min or lower.
- FDA Safety Labeling Changes: [Mescape]
- Doxil (doxorubicin HCl liposome
injection) to warn of adverse events associated with its use. Cumulative
doses of liposomal doxorubicin approaching 550 mg/m2 have been
associated with myocardial damage. Acute left ventricular failure
may occur, particularly in patients who have exceeded the recommended
total cumulative dose of 550 mg/m2. Congestive heart failure or
cardiomyopathy may be encountered after discontinuation of anthracycline
therapy.
- Novamine (15% amino acid injection)
the product contains aluminum that may reach toxic levels with
prolonged administration in patients with impaired kidney function.
Premature neonates are particularly at risk because they have immature
kidneys and require large amounts of calcium and phosphate solutions
that contain aluminum.
- FDA Approvals:
- Baraclude (entecavir)
New treatment for chronic Hepatitis B.FDA
report [News
report]
- Venofer (iron
sucrose)
- Boniva (ibandronate
sodium) to treat or prevent osteoporosis in women after menopause.
- Approval First-of-Kind
Device to Treat Descending Thoracic Aneurysms
- FDA Approvals: [Medscape summary]
- Temodar (temozolomide capsules)
approved a new indication allowing use concomitantly with
radiotherapy and as maintenance treatment in the first-line treatment
of adult patients with glioblastoma multiforme (GBM).
- LR3001 (reverse complimentary
(antisense) oligodeoxynucleotide) approved orphan drug status allowing
use in the treatment of chronic myelocytic leukemia.
- Xopenex HFA hydrofluoroalkane
(levalbuterol tartrate metered-dose inhaler) for the treatment
or prevention of bronchospasm in adults, adolescents, and children
aged four years and older with reversible obstructive airway disease.
- FDA
Talk Paper: FDA Publishes Final Rule on Chlorofluorocarbons in Metered
Dose Inhalers [Albuterol metered-dose inhalers (MDIs) using chlorofluorocarbon
(CFC) propellants must no longer be produced, marketed or sold in the
United States after December 31, 2008]
- FDA Reports
- § Designer
Molecule Stops Cat Allergies. [Science
now and News
report from the April issue of Nature
Medicine.]
- § Listening
to music might act as a painkiller. [BBC report
from British Psychological Society Meeting]