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Recent reports in Science and Medicine for January 2006

Some of these links are very transient and may expire within days of posting. Some may require prior registration. Check-in and view frequently to avoid missing great news items. I welcome any suggested articles. (email link). An "*" indicates a recommended article.

:::::::       January 31      :::::::      
  1. CARDIOLOGY: Recent news
  2. *  Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial. BMJ 2006;332:199-204.
  3. *  Long term outcomes from the IMPACT randomised trial for depressed elderly patients in primary care. BMJ (published 20 January 2006) .
  4. Thiazide diuretic prescription and electrolyte abnormalities in primary care. Br J Clin Pharm 2006; 61: 87-95. [Eurekalert]
:::::::       January 30       :::::::      
  1. JAMA  Vol. 295 No. 4, pp. 355-460, January 25, 2006
  2. *  FDA drug prescribing warnings: is the black box half empty or half full? Pharmacoepidemiol Drug Saf Early Release.
:::::::       January 27        :::::::    
  :::::::  Weekend Reading - Basic Science and general interest articles  :::::::  
  1. FDA News
    • MedWatch:
      • Ketek (telithromycin) Serious liver toxicity following administration of Ketek (telithromycin). FDA Advisory. FDA information. [Medscape]
      • Hydrea and Droxia (hydroxyurea) Revisions to the prescribing information to describe cutaneous vasculitic toxicities, including vasculitic ulcerations and gangrene, in patients with myeloproliferative disorders during therapy with hydroxyurea, most often reported in patients with a history of or currently receiving interferon therapy. [Medscape]
    • FDA Safety Changes:
      • Humira (adalimumab) Warning of the risk for serious infections, neurologic events, and malignancies associated with its use. Some cases of opportunistic infections and tuberculosis have resulted in fatality.
      • Biaxin (clarithromycin) Contraindications associated with its use. Reports of cardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades de pointes) with use of clarithromycin and/or erythromycin in patients receiving cisapride, pimozide, astemizole, or terfenadine. Some of these cases have been fatal. [Medscape]
      • Flomax (tamsulosin) Risk of intraoperative floppy iris syndrome during cataract surgery in patients receiving this or other alpha-1 blockers. [Medscape]
    • FDA Regulations: New Requirements for Prescribing Information.
  2. *  The Power of Repetition in Mastering Cardiac Auscultation. Am J Med 2006; 119: 73-75. Time:Web Exclusive | Science & Health. Updating the Stethoscope with an iPod *   [Eurekalert]
  3. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nature Medicine 12, 83 - 88 (2005)
    Published online: 20 December 2005; | doi:10.1038/nm1347    . [ScienceDaily]
  4. Thinking Thin ScienceNOW Daily News 18 January 2006
  5. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS published Jan 17, 2006, ( Medical Sciences ). [Eurekalert Researchers identify a compound in cocoa responsible for improving blood flow ]
  6. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol. Biol. Cell 2006 17: [Eurekalert: Fat overload kills mammalian cells — key culprit identified]
  7. Bird flu's bodily harm revealed. Nature: Published online: 20 January 2006; | doi:10.1038/news060116-15. Alarms ring over bird flu mutations. Nature news.
  8. Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes. Diabetes 2006 55: 102-109. [Eurekalert: Diabetes complications rooted in faulty cell repair]
  9. Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice. PNAS Published online Jan 23, 2006.
:::::::       January 26       :::::::      
  1. Archives of Internal Medicine Vol. 166 No. 2, pp. 139-250, January 23, 2006
:::::::       January 25      :::::::      
  1. Acetazolamide Improves Central Sleep Apnea in Heart Failure. Am J Respir Crit Care Med 2006; 173: 234-237. [MedNews]
  2. Protective Effect of Fish Oil Supplementation on Exercise-Induced Bronchoconstriction in Asthma. Chest 2006;129:39-49. [Medscape]
  3. * Diagnosis and Management of Cough: ACCP Evidence-Based Clinical Practice Guidelines. Chest 2006;129:1S-23S. [Medscape]
  4. The Salmeterol Multicenter Asthma Research Trial: A Comparison of Usual Pharmacotherapy for Asthma or Usual Pharmacotherapy Plus Salmeterol. Chest 2006 129: 15-26. [Medscape]
  5. Anterior cingulate activity correlates with blood pressure during stress . Psychophysiology 2006; 42: 627 . [Eurekalert]
  6. Effect of a brief intervention on evidence-based medicine skills of pediatric residents. BMC Medical Education 2006, 6:1
  7. A chronic fatigue syndrome - related proteome in human cerebrospinal fluid. BMC Neurology 2005, 5:22 doi:10.1186/1471-2377-5-22. [ScienceDaily]
  8. The use of antidepressants to treat depression in children and adolescents -- A.H. Cheung et al. CMAJ 2006; 174L 193-200.
  9. * Single crossclamp improves 6-month cognitive outcome in high-risk coronary bypass patients: The effect of reduced aortic manipulation. J Thorac Cardiovasc Surg 2006 131: 114-121. [MedNews report]
  10. A 24-Week Open-Label Extension Study of Memantine in Moderate to Severe Alzheimer Disease. Arch Neurol. 2006;63:49-54. [Medscape]
:::::::       January 24       :::::::      
  1. * Severe Hepatotoxicity of Telithromycin: Three Case Reports and Literature Review. Ann Int Med Early Release. [Eurekalert]
  2. * Non-arteritic anterior ischaemic optic neuropathy and the treatment of erectile dysfunction. Br J Ophthalmol 2006; 90: 154-57. [Eurekalert] [BBC Report]
  3. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ, doi:10.1136/bmj.38701.399942.63 (published 18 January 2006)
  4. * Food buying habits of people who buy wine or beer: cross sectional study. BMJ published 20 Jan 2006. [People who buy wine also buy healthier food - Eurekalert] [ScienceDaily]
  5. * Chronic stress at work and the metabolic syndrome: prospective study. BMJ online, doi:10.1136. [Medscape] [Eurekalert]
  6. Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis. BMJ 2006;332:141-145.
  7. New England Journal of Medicine Previous Volume 354 January 19, 2006 Number 3
:::::::       January 23      :::::::      
  1. Expression of Concern: Sudbø J et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-13. Published at www.nejm.org January 20, 2006 (10.1056/NEJMe068020).
  2. Canadian Medical Association Journal 17 January 2006, Volume 174, Issue 2
  3. JAMA Vol. 295 No. 3, pp. 249-348, January 18, 2006
    • * Watchful Waiting vs Repair of Inguinal Hernia in Minimally Symptomatic Men: A Randomized Clinical Trial. JAMA. 2006;295:285-292. [Medscape]
    • Thromboembolic Adverse Events After Use of Recombinant Human Coagulation Factor VIIa. JAMA. 2006;295:293-298.
    • Surveillance for Recurrent Bladder Cancer Using a Point-of-Care Proteomic Assay. JAMA. 2006;295:299-305.
    • Differences in Review Quality and Recommendations for Publication Between Peer Reviewers Suggested by Authors or by Editors. JAMA. 2006;295:314-317.
    • * Review: Aspirin for the Primary Prevention of Cardiovascular Events in Women and Men: A Sex-Specific Meta-analysis of Randomized Controlled Trials. JAMA. 2006;295:306-313. [Eurekalert] [NewScientist]
    • Clinical Crossroads: A 60-Year-Old Woman Who Has Felt Sad for Much of Her Life. JAMA. 2006;295:318-323.
    • Commentaries: The 100 000 Lives Campaign: Setting a Goal and a Deadline for Improving Health Care Quality. JAMA. 2006;295:324-327.
    • Editorials: The Asymptomatic Hernia: "If It's Not Broken, Don't Fix It" JAMA. 2006;295:328-329.
    • From the Centers for Disease Control and Prevention
      • West Nile Virus Activity—United States, January 1–December 1, 2005. JAMA. 2006;295:266-267.
      • Brief Report: Respiratory Syncytial Virus Activity—United States, 2004-2005. JAMA. 2006;295:267-268.
      • Reduction in Central Line–Associated Bloodstream Infections Among Patients in Intensive Care Units—Pennsylvania, April 2001–March 2005. JAMA. 2006;295:269-270.
      • Ninth Annual Conference on Vaccine Research, May 8-10, 2006. JAMA. 2006;295:270.
:::::::       January 20        :::::::    
  :::::::  Weekend Reading - Basic Science and general interest articles  :::::::  
  1. FDA News
    • Approvals: [Medscape]
      • Boniva (injectable ibandronate) for quarterly administration by a healthcare professional in the treatment of postmenopausal osteoporosis.
      • Femara (letrozole) for use in the adjuvant treatment of postmenopausal women with hormone-receptor–positive early breast cancer.
    • FDA Safety Changes:
    • New Prescription Drug Information Format to Improve Patient Safety
    • MedWatch
      • Clozaril (clozapine) revised prescribing information eith modification of the white blood cell monitoring schedule, dementia-related psychosis, parlytic ileus, hypercholesterolemia and pharmacokinetic interaction with citalopram. [Medscape]
  2. * CDC HEALTH ALERT: CDC Recommends against the Use of Amantadine and Rimantadine for the Treatment or Prophylaxis of Influenza in the United States during the 2005–06 Influenza Season. [Medscape]
  3. MMWR January 13, 2006 / Vol. 55 / No. 1 : Nonfatal, Unintentional Medication Exposures Among Young Children: United States, 2001--2003. [Medscape]
  4. * WHO calls for an immediate halt to provision of single-drug artemisinin malaria pills. WHO News release.
  5. * Reversing the defective induction of IL-10–secreting regulatory T cells in glucocorticoid-resistant asthma patients. J. Clin. Invest. 116:146-155 .
  6. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis . J. Clin. Invest. published January 12, 2006. [ScienceDaily]
  7. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J Clin Invest published January 12, 2006.
  8. Soy diet worsens heart disease in mice. J. Clin. Invest. 116:209-216.
  9. * Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics 38, 54 - 62 (2006) .
  10. * (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS published January 17, 2006. [Eurekalert: Heart-healthy compound in chocolate identified.]
:::::::       January 19        :::::::      
  1. *  ACC/AHA Clinical Performance Measures for Adults With ST-Elevation and Non-ST-Elevation Myocardial Infarction. A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures on ST-Elevation and Non-ST-Elevation Myocardial Infarction) Circulation 2006 published online [Eurekalert]
  2. Myocardial Viability Testing and the Effect of Early Intervention in Patients With Advanced Left Ventricular Systolic Dysfunction. Circulation 2006: published online before print January 3, 2006. [Medscape]
  3. Long-Term Adherence to Evidence-Based Secondary Prevention Therapies in Coronary Artery Disease. Circulation 2006: published online January 9, 2006, [Medscape]
  4. * Regular Aspirin-Use Preceding the Onset of Primary Intracerebral Hemorrhage is an Independent Predictor for Death. Stroke 2006;37:4-5,129-133. [Medscape]
  5. * Moderate Alcohol Consumption Reduces Risk of Ischemic Stroke: The Northern Manhattan Study. Stroke 2006 37: 13 - 19. [Medscape]
  6. Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus. J Am Coll Cardiol 2006 47: 65-71. [Medscape]
  7. * Caffeine Decreases Exercise-Induced Myocardial Flow Reserve. J Am Coll Cardiol 2006; 47: 405-410. [Eurekalert]
  8. The Prevalence of Thiamin Deficiency in Hospitalized Patients With Congestive Heart Failure. J Am Coll Cardiol 2006; 47:354-361. [Eurekalert]
  9. * Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans. J Am Coll Cardiol 2006 47: 398-402. [MedNews]
  10. Tooth Loss and Heart Disease: Findings from the Behavioral Risk Factor Surveillance System. Am J Prev Med 2006; 29: 50-56. (ScienceDirect) [Medscape]
  11. Annals of Internal Medicine 17 January 2006 Volume 144 Issue 2
:::::::       January 18      :::::::      
  1. Evaluation of Plasma Homocysteine and Risk of Age-Related Macular Degeneration. Am J Ophth 2006; 141:201-203. [Eurekalert]
  2. Randomized Trial of the Efficacy of Tamsulosin, Nefedipine and Phloroglucinol in Medical Expulsive Therapy for Distal Ureteral Cacluli Therapy. J Urology 2005; 174:167-172.
  3. Familial Lung Cancer: Genetic Susceptibility and Relationship to Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 2006; 173: 16-22. [Eurekalert]
  4. Genetics plays a role in the side effects experienced by people taking painkillers. Gastroenerology [Eurekalert]
  5. A Comparison of Short-term Changes in Health-related Quality of Life in Thyroid Carcinoma Patients Undergoing Diagnostic Evaluation with rhTSH Compared to Thyroid Hormone Withdrawal. J Clin Endocrinol Metab published January 4, 2006. [Eurekalert]
  6. New England Journal of Medicine Volume 354 January 12, 2006 Number 2
:::::::       January 17       :::::::      
  1. * Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis. BMJ published online 10 January 2006.
  2. * A Multicenter Prospective Randomized Study Testing Non-Inferiority of Thalidomide 100 mg/day as Compared with 400 mg/day in Patients with Refractory/Relapsed Multiple Myeloma: First Results of the Final Analysis of the IFM 01-02 Study. Blood (ASH Annual Meeting Abstracts) 2005 106: Abstract 364.
  3. Randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: CLARICOR trial. BMJ 2006;332:22-27.
  4. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ 2006;332:11-17.
  5. Editorial: Magnet therapy. BMJ 2006;332:4 (7 January). [MedNews]
  6. Archives of Internal Medicine Vol. 166 No. 1, pp. 3-127, January 9, 2006
:::::::       January 16      :::::::      
  1. JAMA Vol. 295 No. 2, pp. 131-240, January 11, 2006
  2. Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans. JACC 2006; 47: 398-402. [Eurekalert]
  3. Effect of a Diet and Exercise Intervention on Oxidative Stress, Inflammation, MMP-9 and Monocyte Chemotactic Activity in Men with Metabolic Syndrome Factors. J Appl Physiol (December 15, 2005). [NewScientist]
  4. Cyclic Vomiting Syndrome in 41 adults: the illness, the patients, and problems of management. BMC Medicine 2005, 3:20. [Medscape]
  5. Nurse Staffing In Hospitals: Is There A Business Case For Quality? Health Affairs 2006; 25: 204-211. [Eurekalert: Increasing nursing staff improves safety and quality in hospitals.]
:::::::       January 13        :::::::    
  :::::::  Weekend Reading - Basic Science and general interest articles  :::::::  
  
  1. FDA NEWS:
    • MedWatch: [Medscape]
      • WinRho SDF (Rho(D) Immune Globulin Intravenous [Human]) labeling changes to address two important safety concerns. Continued postmarketing safety surveillance has shown rare, but severe and sometimes fatal, intravascular hemolysis and potentially serious complications, including:
        1. Disseminated intravascular coagulation in patients with ITP. P
        2. Maltose in the liquid formulation of WinRho SDF has been shown to give falsely high blood glucose levels in certain types of blood glucose testing systems.
    • FDA Safety Changes: [Medscape]
      • Vytorin (ezetimibe/simvastatin) warning of a drug interaction between its simvastatin component and fibrates (especially gemfibrozil) that increases the risk for myopathy.
      • Efudex (fluorouracil topical) safety labeling for to advise against its use in patients with dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.
      • Prinivil (lisinopril) safety labeling revisions to warn of the rare risk for head/neck angioedema and hepatic failure associated with its use.
    • FDA Approvals: [Medscape]
      • CellCept (mycophenolate mofetil) approved orphan drug status for the treatment of myasthenia gravis (MG).
      • Prochymal (adult stem cell product) approved orphan drug status for the treatment of acute graft-versus-host disease (GVHD).
      • Shiga Toxin Antibodies (chimeric anti-Shiga toxin antibodies {caStx1 and caStx2}) orphan drug status for the treatment of Shiga toxin–producing Escherichia coli (STEC) infections.
  2. * Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States. Science 2006: 311: 77 - 80.
  3. * Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3. J Gen Virol 87 (2006), 1-10. [ScienceDaily: Researchers Develop New Vaccine Candidate Against Hepatitis C]
  4. Polyphosphate modulates blood coagulation and fibrinolysis. PNAS published January 12, 2006.
:::::::       January 12        :::::::      
  1. * A Comprehensive Immunization Strategy to Eliminate Transmission of Hepatitis B Virus Infection in the United States. Recommendations of the Advisory Committee on Immunization Practices (ACIP) Part 1: Immunization of Infants, Children, and Adolescents. Recommendations and Reports. MMWR Dec 23, 2005 / 54(RR16);1-23. [Medscape]
  2. * Etiologies of Nongonococcal Urethritis: Bacteria, Viruses, and the Association with Orogenital Exposure. JID 2006;193:336-345.
  3. * Prevalence of Staphylococcus aureus Nasal Colonization in the United States, 2001 - 2002 . JID 2006;193:172-179. [Medscape] [Editorial]
  4. * Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation. Br J Ophthalmol 2006; 90: 75-80. [Science Daily]
  5. The PREMIER Study: A Multicenter, Randomized, Double-Blind Clinical Trial of Combination Therapy With Adalimumab Plus Methotrexate Versus Methotrexate Alone or Adalimumab Alone in Patients with Early, Aggressive Rheumatoid Arthritis Who Had Not Had Previous Methotrexate Treatment. Arth & Rheum 2006, 54:1: 41-52. [Eurekalert] [Medscape]
  6. Subjective Complaints Precede Parkinson Disease. Arch Neurol. 2006;63:(early release). [Medscape]
  7. Effects of Testosterone on Cognition and Mood in Male Patients With Mild Alzheimer Disease and Healthy Elderly Men. Arch Neurol. 2006;63: (early release). [ScienceDaily]
  8. Response Profiles to Fluticasone and Montelukast in Mild-to-Moderate Persistent Childhood Asthma J Allergy Clin Imm 2006; 117: 45-52. [Eurekalert]
  9. Ropinirole in the Treatment of Patients With Restless Legs Syndrome: A US-Based Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Mayo Clin Proc. 2006;81:17-27. [Medscape]
  10. Exercise Accelerates Wound Healing Among Healthy Older Adults: A Preliminary Investigation. J Gerontol A Biol Sci Med Sci 2005 60: 1432-1436.
:::::::       January 11      :::::::      
  1. * Patients' Expectations and Satisfaction in Lumbar Spine Surgery. Spine. 30(23):2689-2694, December 1, 2005. [Medscape]
  2. * Natural history of depression in the oldest old: Population-based prospective study. Br J Psychiatry 2006 188: 65-69. [MedNews]
  3. Frontline Treatment of Combat Stress Reaction: A 20-Year Longitudinal Evaluation Study. Am J Psychiatry 2005 162: 2309-2314. [Medscape]
  4. How Should Remission From Depression Be Defined? The Depressed Patient’s Perspective. Am J Psychiatry 2006 163: 148-150. [Eurekalert]
  5. Beyond Efficacy: The STAR*D Trial. Am J Psychiatry 2006 163: 5-7. [Eurekalert]
  6. Suicide Risk During Antidepressant Treatment. Am J Psychiatry 2006 163: 41-47. [Eurekalert]
  7. New England Journal of Medicine Volume 354 January 5, 2006 Number 1
:::::::       January 10      :::::::      
  1. * Effects of Acute Exercise on Mood and Well-Being in Patients with Major Depressive Disorder. Med Sci Sports Exerc. 2005;37:2032-2037. [Eurekalert]
  2. * Effects of Alcohol Advertising Exposure on Drinking Among Youth. Arch Pediatr Adolesc Med. 2006;160:18-24. [Eurekalert]
  3. Impact of Adolescent Mental Disorders and Physical Illnesses on Quality of Life 17 Years Later. Arch Pediatr Adolesc Med. 2006;160:93-99.
  4. Enabling Parents Who Smoke to Prevent Their Children From Initiating Smoking. Results From a 3-Year Intervention Evaluation. Arch Pediatr Adolesc Med. 2006;160:56-62.
  5. Neighborhood Safety and Overweight Status in Children. Arch Pediatr Adolesc Med. 2006;160:25-31.
  6. Intrinsic Abnormalities of Lymphocyte Counts in Children with Down Syndrome. J Pediatr 2005;147: 744-752. [Medscape]
  7. Cheerleading-Related Injuries to Children 5 to 18 Years of Age: United States, 1990–2002. Pediatrics 2006; 117: 122-129.
  8. Annals of Internal Medicine 3 January 2006 Volume 144 Issue 1
    • Changes in Invasive Pneumococcal Disease among HIV-Infected Adults Living in the Era of Childhood Pneumococcal Immunization. Flannery, and others.
    • * Physical Performance in Peripheral Arterial Disease: A Slower Rate of Decline in Patients Who Walk More. McDermott, and others. [Eurekalert]
    • Body Mass Index and Risk for End-Stage Renal Disease. Hsu, and Others. [Eurekalert]
    • Who Is Maintaining Certification in Internal Medicine—and Why? A National Survey 10 Years after Initial Certification. Lipner, and Others . [Eurekalert]
    • Update in Infectious Diseases. Bartlett
    • REVIEWS: Meta-Analysis: Protein and Energy Supplementation in Older People. Milne, Avenell, and Potter.
    • EDITORIALS: Leaving (Internal) Medicine. Sox
    • Feeding Patients after Stroke: Who, When, and How. Williams
    • ON BEING A DOCTOR: Customer Disservice? Glazer
    • Twenty Minutes: Cavanaugh
    • Commentary: Customer Disservice? Brennan
:::::::       January 9       :::::::      
  1. * Renal Function, Congestive Heart Failure, and Amino-Terminal Pro-Brain Natriuretic Peptide Measurement: Results From the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study. J Am Coll Cardiol 2006 47: 91-97. [Science Daily]
  2. * Women with a low Framingham risk score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis. Am Heart J; 2005: 1276-1281. [Eurekalert]
  3. Controversies in Cardiovascular Medicine: Noninvasive Screening for Coronary Artery Disease With Computed Tomography Is Useful. How useful is computed tomography for screening for coronary artery disease? Circulation. 2006;113:125-146.
  4. * A critique of the Women’s Health Initiative hormone therapy study. Fertil Steril 2005;6:1589-1601. [Medscape]
  5. * Clarithromycin reduces recurrent cardiovascular events in patients without periodontitis. S Puja, and Others. Atherosclerosis online Jan 4 2006. [Eurekalert]
  6. New England Journal of Medicine Volume 353 December 29, 2005 Number 26
:::::::       January 6        :::::::    
  :::::::  Weekend Reading - Basic Science and general interest articles  :::::::  
  
  1. MedWatch:
  2. FDA Approvals [Medscape] and Safety Changes: [Medscape]
  3. * Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation. H-S Yin et al. Nature 439, 38-44 (5 Jan 2006) [Eurekalert: Structure of viral harpoon protein reveals how viruses enter cells]
  4. * Dietary and Genetic Control of Glucose Transporter 2 Glycosylation Promotes Insulin Secretion in Suppressing Diabetes. Cell, Vol 123, 1307-1321, 29 December 2005. [Eurekalert: How a high-fat diet causes type 2 diabetes]
  5. Stem cell mobilization by hyperbaric oxygen. Am J Physiol Heart Circ Physiol (November 18, 2005). doi:10.1152/ajpheart.00888.2005 . [Eurekalert]
  6. Integration of Endocannabinoid and Leptin Signaling in an Appetite-Related Neural Circuit. Neuron, Vol 48, 1055-1066, 22 December 2005. [ScienceNOW]
  7. Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. JCI; online December 22, 2005. [ScienceDaily]
:::::::       January 5       :::::::      
  1. JAMA Vol. 295 No. 1, pp. 9-124, January 4, 2006
  2. JAMA Vol. 294 No. 24, pp. 3057-3200, December 28, 2005
:::::::       January 4       :::::::      
  1. Annals of Internal Medicine 20 December 2005 Volume 143 Issue 12
    • * Comparing Yoga, Exercise, and a Self-Care Book for Chronic Low Back Pain: A Randomized, Controlled Trial. KJ Sherman, and Others. [Medscape]
    • Empirical Anti-Candida Therapy among Selected Patients in the Intensive Care Unit: A Cost-Effectiveness Analysis. Y Golan, and Others.
    • Meta-Analysis: The Efficacy of Strategies To Prevent Organ Disease by Cytomegalovirus in Solid Organ Transplant Recipients. AC Kalil, and Others.
    • Improving Patient Care: Effect of Increasing the Intensity of Implementing Pneumonia Guidelines: A Randomized, Controlled Trial. DM Yealy, and Others.
    • Review: New Concepts in the Pathophysiology of Inflammatory Bowel Disease. G Bamias,and Others.
    • Perspectives: Letter from New Orleans. KB DeSalvo
    • History of Medicine: The Discovery of Insulin: The Rochester, New York, Connection. R Madeb, and Others.
    • Editorials: Controlling the Troll: Management of Cytomegalovirus Infection after Transplantation. S Dummer.
    • On Being a Doctor: The Man with No Heart. A Mosenkis.
  2. Archives of Internal Medicine Vol. 165 No. 22, pp. 2551-2719, Dec 12/26, 2005
:::::::       January 3      :::::::      
  1. JAMA Vol. 294 No. 23, pp. 2943-3048, December 21, 2005
  2. Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis. Circulation 2005;112:3930-3936. [Medscape]
  3. Pharmacotherapy Primer – Based on the ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
  4. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ, doi:10.1136.
  5. * The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS). Am Heart J. 2005; 150(5):1032-1038. [Medscape]
:::::::       January 2       :::::::      
  1. New England Journal of Medicine Volume 353 December 22, 2005 Number 25
  2. Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis: Recommendations from the National Tuberculosis Controllers Association and CDC. Published in the December 16 MMWR: Recommendations and Reports. [Medscape] (pdf of issue)
  3. The Effects of Pulmonary Rehabilitation in the National Emphysema Treatment Trial. Chest 2005;128: 3799-3809. Editorial: 3783-3784 [Medscape]
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