Recent
reports in Science and Medicine for September 2005
Some
of these links are very transient and may expire within days of posting.
Some may require prior registration. Check-in and view frequently to
avoid missing great news items. I welcome any suggested articles. (email
link). An "*" indicates
a recommended article.
| ::::::: September
30 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles ::::::: |
|
- FDA News: Public
Health Advisory on Strattera (Atomoxetine) for Attention Deficit
Disorder. (boxed warning and additional warning statements regarding
an increased risk of suicidal thinking in children and adolescents)
- FDA Medwatch:
- Paxil (paroxetine)
Changes in Pregnancy/PRECAUTIONS. Results of a GSK retrospective
epidemiologic study of major congenital malformations in infants
born to women taking antidepressants during the first trimester of
pregnancy suggested an increase in the risk of overall major congenital
malformations [OR 2.2; 95% confidence interval, 1.34-3.63]. Healthcare
professionals are advised to carefully weigh the potential risks
and benefits of using paroxetine therapy in women during pregnancy
and to discuss these findings as well as treatment alternatives with
their patients. [Medscape]
- Toprol-XL (metoprolol
extended release) Reports of medication dispensing or prescribing errors
between Toprol-XL and Topamax. There have also been reports of medication
errors involving confusion between Toprol-XL and Tegretol or Tegretol-XR.
[Medscape]
- Strattera (atomoxetine)
a boxed warning and additional warning statements that alert health
care providers of an increased risk of suicidal thinking in children
and adolescents.
- FDA Safety Labeling Changes: [Medscape]
- Hectorol (doxercalciferol) revision
of treatment recommendations for hypercalcemia and hyperphosphatemia
secondary to its use.
- Mevacor (lovastatin) drug interactions
that increase the risk of myopathy/rhabdomyolysis associated with its
use.
- Pulmicort (budesonide inhalation
suspension ) increased risk of infection associated with its use at
immunosuppressant doses.
- FDA Approvals: [Medscape]
- Lipitor (atorvastatin) for the
reduction of risk of myocardial infarction (MI) and stroke in patients
with type 2 diabetes and no evidence of coronary heart disease, but
having multiple risk factors such as retinopathy, albuminuria, smoking,
or hypertension.
- Arimidex (anastrozole) for adjuvant
treatment of postmenopausal women with hormone receptor–positive
early invasive breast cancer.
- Tramadol ER for chronic moderate
to moderately severe pain requiring around-the-clock therapy for an
extended time.
- Perturbations in O-linked -N-Acetylglucosamine Protein Modification Cause
Severe Defects in Mitotic Progression and Cytokinesis. J.
Biol. Chem. 2005 280: 32944-32956. [Eurekalert:
Sugar helps control cell division]
- * Targeting
BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic
model. Nature:
Neuroscience Published online: 28 August 2005; | doi:10.1038/nn1531.
[ScienceDaily :
Targeting A Key Enzyme With Gene Therapy Reversed Course Of Alzheimer's
Disease In Mouse Models. ]
- Women Better at Hand Hygiene Habits, Hands Down. Washup.org Press
release
- * MMWR:
Concussion Tool Kit for High School Coaches and More. [Medscape] MMWR.
2005;54;917-948
- Diagnosis and Management of Injuries From Dangerous Marine Life [Medscape]
- * Introduction
to Cardiothoracic Imaging, Yale University School of Medicine.
| ::::::: September
29 ::::::: |
|
- * Carotid endarterectomy—An
evidence-based review: Report of the Therapeutics and Technology Assessment
Subcommittee of the American Academy of Neurology. Neurology
2005 65: 794-801. [Medscape]
- Homocysteine and Cognitive Performance in the Framingham Offspring Study:
Age Is Important. Am.
J. Epidemiol. 2005 162: 644-653. [Eurekalert]
[News-Med]
- * Guideline-Based
Standardized Care Is Associated With Substantially Lower Mortality in Medicare
Patients With Acute Myocardial Infarction: The American College of Cardiology’s
Guidelines Applied in Practice (GAP) Projects in Michigan. J
Am Coll Cardiol 2005 46: 1242-1248. [Eurekalert]
- Atherothrombosis and High-Risk Plaque: Part II: Approaches by Noninvasive
Computed Tomographic/Magnetic Resonance Imaging. J
Am Coll Cardiol 2005 46: 1209-1218.
- JAMA Vol.
294 No. 12, pp. 1463-1580, September 28, 2005
| ::::::: September
28 ::::::: |
|
- Metabolic Imaging With -Methyl-p-[123I]-Iodophenyl-Pentadecanoic Acid
Identifies Ischemic Memory After Demand Ischemia. Circulation
2005: published online Sept 26, 2005. [Eurekalert]
[[News-Medical.net]
- Gamma-Glutamyltransferase as a Risk Factor for Cardiovascular Disease
Mortality. An Epidemiological Investigation in a Cohort of 163 944 Austrian
Adults. Circulation
2005: published online Sept 26, 2005. [Medscape] [Eurekalert]
- Archives
of Internal Medicine Vol. 165 No. 17, pp. 1933-2040, September 26, 2005
| ::::::: September
27 ::::::: |
|
- Ascending Thoracic Aneurysms Are Associated With Decreased Systemic Atherosclerosis. Chest
2005 128: 1580-1586. [Eurekalert]
- * Aerobic
exercise and its impact on musculoskeletal pain in older adults: a 14 year
prospective, longitudinal study. Arthritis
Research & Therapy 2005, 7:R1263-R1270. [Eurekalert]
- Mayo Clinic Develops New Coma Measurement System. Tool quantifies level
of consciousness, severity of brain injury. [Mayo
Clinic News] October issue of Annals
of Neurology, to be published online Friday, Sept. 9. [Eurekalert]
- Diabetes Mellitus Is Associated With an Increased Risk of Falls in Elderly
Residents of a Long-Term Care Facility. J
Gerontol A Biol Sci Med Sci 2005 60: 1157-1162. [Eurekalert]
- High homocysteine and low B vitamins predict cognitive decline in aging
men: the Veterans Affairs Normative Aging Study. Am
J Clin Nutr 2005 82: 627-635.
- Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am
J Clin Nutr 2005 82: 636-643.
| ::::::: September
26 ::::::: |
|
- Aspirin Use in Older Patients With Heart Failure and Coronary Artery
Disease: National Prescription Patterns and Relationship With Outcomes. J
Am Coll Cardiol 2005 46: 955-962. [Access
via Cardiosourcce]
- Inhibition of Awake Sympathetic Nerve Activity of Heart Failure Patients
With Obstructive Sleep Apnea by Nocturnal Continuous Positive Airway Pressure. J
Am Coll Cardiol, 2005; 45:2008-2011.
- New
England Journal of Medicine Volume 353 September 22, 2005
Number 12
| ::::::: September
23 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles ::::::: |
|
- FDA Safety Labeling Changes: [Medscape]
- Camptosar (irinotecan) reduced
dosing in patients who are homozygous for the UDP-glucuronosyltransferase
1A1 (UGT1A1)–*28 allele.
- Keppra (levetiracetam) risks of somnolence,
fatigue, and behavioral abnormalities associated with its use in pediatric
patients.
- Prempro/Premphase (conjugated estrogens/medroxyprogesterone
acetate) risks of cardiovascular disorders, probable dementia, and
endometrial cancer associated with their use.
- Drug Firms Launch Web Site to Disclose Trials Data [Medscape] International
Federation of Pharmaceutical Manufacturers and Association Portal
- Psoriasis-like skin disease and arthritis caused by inducible epidermal
deletion of Jun proteins. Nature
(15 Sep 2005) 437, 369-375. (Probing the Cause of Psoriasis. [ScienceNOW]
- Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic
Pulmonary Fibrosis. PLoS
Medicine Vol. 2, No. 9, e251 DOI: 10.1371. [Medical
Study News]
- Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness
after Vaccination Using a Functional Microarray. PLoS
Medicine Vol. 2, No. 10, e265 DOI: 10.1371
- Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free
Survival in Breast Cancer. PLoS
Medicine Vol. 2, No. 9, e284 DOI: 10.1371. [ News-Medical.Net ]
- Women doctors and their careers: what now? BMJ
2005;331:569-572 [Eurekalert]
- Science
NOW: Weakening drug-related memories by interfering with molecular
signals in the brain's reward pathways.
- Top-down suppression deficit underlies working memory impairment in normal
aging. Nature
Neuroscience: Brief Communication published online: 11 September 2005;
| doi:10.1038/nn1543. [Eurekalert:
Memory loss in older adults due to distractions, not inability to focus]
- Agouti-related peptide−expressing neurons are mandatory for feeding. Nature:
Neuroscience Published online: 11 September 2005; | doi:10.1038/nn1548 [Eurekalert:
Eating and body weight regulated by specific neurons]
| ::::::: September
22 ::::::: |
|
- PRESERVE-ß: Two-year efficacy and safety of initial combination
therapy with nateglinide or glyburide plus metformin. Diabetes
Care 28:2093-2099, 2005. [Medscape]
- Epithelial Barrier Function In Vivo Is Sustained Despite Gaps in Epithelial
Layers. Gastroent.
2005;129: 902-912. [Eurekalert]
- Focus Issue: ASPIRIN: Sept.
20, 2005, J Am Coll Cardiol. [Access
via Cardiosourcce][ Eurekalert]
- A Randomized Clinical Trial of the Management of Esophageal Coins in
Children. Pediatrics.
2005;116:614-619. [Medscape]
- JAMA
Vol. 294 No. 11, pp. 1307-E8, September 21, 2005
| ::::::: September
21 ::::::: |
|
- * Antibiotic
Dosing in Critically Ill Adult Patients Receiving Continuous Renal Replacement
Therapy. Clin
Inf Dis 2005;41:L000 published online.
- * Antibiotic
Treatment of Acne May Be Associated With Upper Respiratory Tract Infections. Arch
Dermatol. 2005;141:1132-1136. [Eurekalert]
- * The relationship
between primary care antibiotic prescribing and bacterial resistance in
adults in the community: a controlled observational study using individual
patient data. JAC
Advance Access published online on May 31, 2005.
- * Detection
of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential
Role of the Chemokine Mig in Pathogenesis. Clin
Inf Dis 2005;41:1089-1096
- Guidelines
for the Treatment of Community-acquired Pneumonia: Predictors of Adherence
and Outcome. Am.
J. Respir. Crit. Care Med. 2005; 172: 757-762. [Medscape]
- Annals of Internal
Medicine 20 September 2005 Volume 143 Issue 6
- A Comparison of Brand-Name Drug Prices between Canadian-Based Internet
Pharmacies and Major U.S. Drug Chain Pharmacies. Quon
and Others.
- A Health System Program To Reduce Work Disability Related to Musculoskeletal
Disorders. Abásolo
and Others.
- Efficacy and Safety of Second-Generation Antidepressants in the
Treatment of Major Depressive Disorder. Hansen
and Others. [Medscape]
- Meta-Analysis: Chronic Disease Self-Management Programs for Older
Adults. Chodoshand
Others.
- Premalignant and In Situ Breast Disease: Biology and Clinical
Implications. Arpino
and Others.
- Moving beyond Round Pegs and Square Holes: Restructuring Medicare
To Improve Chronic Care. Wolff
and Others.
- Chronic Disease Care: Rearranging the Deck Chairs. Lawrence
- Influenza A (H5N1): Will It Be the Next Pandemic Influenza? Are
We Ready? Bartlett
and Hayden
- On Being
a Doctor: A Page from My Oncology Fellowship
| ::::::: September
20 ::::::: |
|
- Major Risk Factors for Intracerebral Hemorrhage in the Young Are Modifiable. Stroke
2005 36: 1881 - 1885. [Medscape]
- Gender Differences in the Risk of Ischemic Stroke and Peripheral Embolism
in Atrial Fibrillation. The AnTicoagulation and Risk factors In Atrial
fibrillation (ATRIA) Study. Circulation
2005: published online September 12, 2005. [Eurekalert]
- Enhanced Risk Assessment in Asymptomatic Individuals With Exercise Testing
and Framingham Risk Scores. Circulation
2005 112: 1566 - 1572.[Eurekalert]
- Alcohol Consumption and Risk of Atrial Fibrillation in Men and Women.
The Copenhagen City Heart Study. Circulation
2005: published online September 12, 2005, 10.1161. [Medscape]
- *Diagnosis and
Management of the Metabolic Syndrome. An American Heart Association/National
Heart, Lung, and Blood Institute Scientific Statement. Executive Summary. Circulation
2005: published online before print September 12, 2005, 10.1161. [Medscape:
New Guidelines for Diagnosis and Management of Metabolic Syndrome].
- New
England Journal of Medicine Volume 353 September 15, 2005
Number 11
| ::::::: September
19 ::::::: |
|
- Obesity as a risk factor in venous thromboembolism. Am
J Med 2005; 118: 978-980. [Eurekalert]
- Hemodynamic effects of ephedra-free weight-loss supplements in humans
. Am J Med. 2005;118:998-1003.
[Medscape: Ephedra-Free
Weight Loss Supplements May Have Significant Cardiovascular Effect]
- AJM theme issue: Obesity and diabetes. Practice tips: How to intervene
with overweight and obese patients. Am
J Med 2005; 118: 936-938.
- JAMA Vol.
294 No. 10 September 14, 2005.
- Comparison of a Polymer-Based Paclitaxel-Eluting
Stent With a Bare Metal Stent in Patients With Complex Coronary
Artery Disease: A Randomized Controlled Trial. JAMA.
2005;294:1215-1223.
- Effect of Clopidogrel Pretreatment Before Percutaneous
Coronary Intervention in Patients With ST-Elevation Myocardial
Infarction Treated With Fibrinolytics: The PCI-CLARITY Study. JAMA.
2005;294:1224-1232.
- Comparison of Conventional-Dose vs High-Dose Conformal
Radiation Therapy in Clinically Localized Adenocarcinoma of the
Prostate: A Randomized Controlled Trial. JAMA.
2005;294:1233-1239.
- Risk-Treatment Mismatch in the Pharmacotherapy
of Heart Failure. JAMA.
2005;294:1240-1247. [Medscape]
- Insurance Status and Access to Urgent Ambulatory
Care Follow-up Appointments. JAMA.
2005;294:1248-1254.
- Trends in the Leading Causes of Death in the United
States, 1970-2002. JAMA.
2005;294:1255-1259.
- Tumor-Induced Osteomalacia. JAMA.
2005;294:1260-1267.
- Editorials: Paclitaxel-Eluting Stents in Complex
Lesions. JAMA.
2005;294:1268-1270.
- Clopidogrel for Percutaneous Coronary Revascularization:
Time for More Pretreatment, Retreatment, or Both? JAMA.
2005;294:1271-1273.
- Radiation Dose Escalation as Treatment for Clinically
Localized Prostate Cancer: Is More Really Better? JAMA.
2005;294:1274-1276.
| ::::::: September
16 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles :::::::
|
|
- FDA Approvals: [Medscape]
- Nevanac (nepafenac ophthalmic suspension)
for the treatment of pain and inflammation associated with cataract
surgery.
- Sugar-Free Actiq (oral transmucosal
fentanyl citrate) for the management of breakthrough pain in patients
with malignancies who are already receiving and are tolerant of opioid
therapy for their underlying persistent cancer pain.
- Quinine Sulfate 324-mg capsules for
the treatment of uncomplicated Plasmodium falciparum malaria.
- MedWatch: Erbitux (cetuximab)
changed the prescribing information about specific recommendations on observation
periods following infusion. Labeling has been revised to reflect an increased
incidence of hypomagnesemia and recommendations for electrolyte monitoring.
- MMWR: Hurricane
Katrina Response and Guidance for Health-Care Providers, Relief Workers,
and Shelter Operators [Medscape and Medscape]
- MMWR. 2005;54;841-864:
Rising Numbers of Overweight Children/Teens Underscore Need for Early Intervention
and More [Medscape]
- Agouti-related peptide-expressing neurons are mandatory for feeding. Nature:
Neuroscience published online: 11 September 2005 |
- Estrogen down-regulation of the corepressor N-CoR: Mechanism and implications
for estrogen derepression of N-CoR-regulated genes. PNAS
published Sept 1, 2005, 10.1073. [Eurekalert:
Estrogen's role in breast-cancer cell growth]
- Why dietary restriction substantially increases longevity in animal models
but won’t in humans. Ageing Research Reviews 2005; 4: 339-350.(Science
Direct access)
- Fusion to Listeriolysin O and Delivery by Listeria monocytogenes Enhances
the Immunogenicity of HER-2/neu and Reveals Subdominant Epitopes in the
FVB/N Mouse. J
Immunol 2005 175: 3663-3673. [News:
Breast Tumors in Mice Eradicated Using Cancer Vaccine]
- Toluidine blue dye reveals oral cancers. simple dye as a litmus test
to identify abnormal areas of the mouth that may become cancers.
According to a study published in the September
1 issue of Cancer Research, th [News report]
| ::::::: September
15 ::::::: |
|
- * The Routine
Use of Antibiotics to Promote Animal Growth Does Little to Benefit Protein
Undernutrition in the Developing World. Clin
Inf Dis 2005;41:1007-1013. [News
report]
- * Reduction of
Antibiotic Use in the Community Reduces the Rate of Colonization with Penicillin
GNonsusceptible Streptococcus pneumoniae. Clin
Inf Dis 2005;41:930-938. [Eurekalert and ScienceDaily]
- MRSA bacteraemia in patients on arrival in hospital: a cohort study in
Oxfordshire 1997-2003. BMJ,
doi:10.1136/bmj.38558.453310.8F (published 9 September 2005) [Medscape and Eurekalert]
- Effectiveness of treatment for alcohol problems: findings of the randomised
UK alcohol treatment trial (UKATT). BMJ
2005;331:541.
- Cost effectiveness of treatment for alcohol problems: findings of the
randomised UK alcohol treatment trial (UKATT): BMJ
2005;331:544. [Eurekalert:
Treatments for alcohol abuse save society five times as much as they cost]
- Tetraparesis associated with colchicine is probably due to inhibition
by verapamil of the P-glycoprotein efflux pump in the blood-brain barrier. BMJ,
doi:10.1136/bmj.38568.639688.F7
- Recent Use of Oral Contraceptives and the Risk of Multiple Sclerosis. Arch
Neurol. 2005;62:1362-1365.[Medscape]
- The Lancet Volume 366, Issue 9487 , 27 August 2005-2 September
2005 (accesss: ScienceDirect)
- Artesunate versus quinine for treatment of severe
falciparum malaria: a randomised trial. Lancet 2005;366: 717-725.
[Eurekalert]
- Are the clinical effects of homoeopathy placebo
effects? Comparative study of placebo-controlled trials of homoeopathy
and allopathy. The Lancet 2005; 366:726-732.
- End-of-life: the Islamic view. The Lancet 2005;
366:774-779.
- Reduced Drug Dose in Obese Women With Breast Cancer
May Jeopardize Outcome. Lancet 2005; 366, Issue 9486, 634. [Medscape]
- Depletion of latent HIV-1 infection in vivo: a
proof-of-concept study. Lancet 366: 549-555, 2005.
- Valproic acid: a potential role in treating latent
HIV infection. Lancet 366: 523-524, 2005.
- International subarachnoid aneurysm trial (ISAT)
of neurosurgical clipping versus endovascular coiling in 2143 patients
with ruptured intracranial aneurysms: a randomised comparison of
effects on survival, dependency, seizures, rebleeding, subgroups,
and aneurysm occlusion. The
Lancet 2005; 366:809-817.
| ::::::: September
14 ::::::: |
|
- Prognostic Factors and Outcome of Core Binding Factor Acute Myeloid Leukemia
Patients With t(8;21) Differ From Those of Patients With inv(16): A Cancer
and Leukemia Group B Study. JCO
Aug 20 2005: 5705-5717.
- * Insights into
Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human
Neutrophils. J
Immunol 2005 175: 3907-3919. [Eurekalert]
- Archives
of Internal Medicine Vol. 165 No. 16 September
12, 2005
| ::::::: September
13 ::::::: |
|
- Injuries Missed by Limited Computed Tomographic Imaging of Patients With
Cervical Spine Injuries. Annals
of Emergency Medicine online 5 September 2005 [News]
- Randomized Trial of Letrozole Following Tamoxifen as Extended Adjuvant
Therapy in Receptor-Positive Breast Cancer: Updated Findings from NCIC
CTG MA.17. J
Natl Cancer Inst 2005; 97: 1262-1271 [News]
- New
England Journal of Medicine Volume 353 September 8, 2005 Number 10
| ::::::: September
12 ::::::: |
|
- * Perindopril-Based
Blood Pressure-lowering Reduces Major Vascular Events in Patients With
Atrial Fibrillation and Prior Stroke or Transient Ischemic Attack. Stroke
ASAP published Sept 1, 2005.[Medscape]
- Effects of Blood Pressure Lowering on Cerebral White Matter Hyperintensities
in Patients With Stroke. The PROGRESS (Perindopril Protection Against Recurrent
Stroke Study) Magnetic Resonance Imaging Substudy. Circulation
2005: published online before print. Sept 6, 2005. [Medscape]
- JAMA.Vol.
294 No. 9 September 7, 2005
| ::::::: September
9 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles :::::::
|
|
- FDA Approvals: [Medscape]
- ProQuad (attenuated
live virus vaccine containing measles, mumps, rubella, and varicella
viruses) for use in children aged 12 months to 12 years.
- Ambien CR (extended-release formulation
of zolpidem tartrate) for the treatment of insomnia characterized by
difficulties with sleep onset and/or sleep maintenance
- Singulair (montelukast) new indication
for once-daily use for the relief of symptoms of perennial allergic
rhinitis (PAR) in patients aged six months and older.
- FDA Approvals: [Medscape]
- Amplimexon (imexon) indication for
the treatment of ovarian cancer.
- AP23573 (rapamycin analog) approved
orphan drug and fast-track status for the treatment of soft-tissue
and bone sarcomas.
- TQ-1017 (tramadol) second orphan drug
indication for use in the management of postherpetic neuralgia.
- FDA Safety Labeling Changes [Medscape]
- Activella (estradiol/norethindrone)
use of the tablets associated with increased risks of cardiovascular
events, breast and endometrial cancer in postmenopausal women,
and probable dementia in those aged 65 years and older.
- Duramorph PF (morphine) use
may cause severe hypotension in individuals whose ability to maintain
blood pressure has already been compromised by a depleted blood
volume or concurrent administration of drugs such as phenothiazines
or general anesthetics.
- Nutropin (somatropin [rDNA
origin]) use only for the long-term treatment of genetically confirmed
Prader-Willi syndrome in pediatric patients also diagnosed with
growth hormone (GH) deficiency.
- * Why Most Published
Research Findings Are False. John P. A. Ioannidis. PLoS
2005; 2: August 30, 2005 DOI: 10.1371/journal.pmed.0020124
| ::::::: September
8 ::::::: |
|
- Annals of Internal
Medcine 6 September 2005 Volume 143 Issue 5
- Prevention of Exacerbations of Chronic Obstructive
Pulmonary Disease with Tiotropium, a Once-Daily Inhaled Anticholinergic
Bronchodilator: A Randomized Trial. Niewoehner,
and Others.
- Amiodarone Prophylaxis Reduces Major Cardiovascular
Morbidity and Length of Stay after Cardiac Surgery: A Meta-Analysis. Aasbo,
and Others.
- Comparison of Rosiglitazone and Metformin for Treating
HIV Lipodystrophy: A Randomized Trial. Van
Wijk, and Others.
- Update in Gastroenterology and Hepatology. Koretz
and Lipman
- History of Medicine: Anorectics on Trial: A Half Century
of Federal Regulation of Prescription Appetite Suppressants. Colman
- Clinical Guidelines: Genetic Risk Assessment and BRCA
Mutation Testing for Breast and Ovarian Cancer Susceptibility: Recommendation
Statement. U.S.
Preventive Services Task Force*
- Genetic Risk Assessment and BRCA Mutation Testing for
Breast and Ovarian Cancer Susceptibility: Systematic Evidence Review
for the U.S. Preventive Services Task Force. Nelson,
and Others.
- Therapeutic Gains of Prolonged Bronchial Dilatation
in Chronic Obstructive Pulmonary Disease. Turino [Medscape]
- Taking Family History Seriously. Burke
| ::::::: September
7 ::::::: |
|
- * Combined Chemoradiotherapy
Regimens of Paclitaxel and Carboplatin for Locally Advanced Non–Small-Cell
Lung Cancer: A Randomized Phase II Locally Advanced Multi-Modality Protocol. JCO
online Sep 1 2005: 5883–5891. [ScienceDaily News]
- Increased Risk of Demyelinating Diseases in Patients with Inflammatory
Bowel Disease, Gupta, et al. Gastroenterology
2005; 129: 819-826 [Eurekalert]
- The Clustering of Other Chronic Inflammatory Diseases in IBD: A Population-Based
Study, Bernstein, et al. Gastroenterology
2005; 129: 827-836 [Eurekalert]
- * Combination
therapy with lenalidomide plus dexamethasone (REV/DEX) for newly diagnosed
myeloma. Blood
prepublished online Aug 23, 2005 [News
report Eurekalert]
- * Revised Adult
Treatment Panel III Guidelines and Cardiovascular Disease Mortality in
Men Attending a Preventive Medical Clinic. Circulation
2005: published onlineA.105.548198.
- Aromatase inhibitors and the syndrome of arthralgias with estrogen deprivation. Arthr & Rhem
2005 52: 2594-2598. [Eurekalert]
- Is the disease course of rheumatoid arthritis becoming milder?: Time
trends since 1985 in an inception cohort of early rheumatoid arthritis. Arthr & Rheum
2005; 52: 2616-2624. [Eurekalert]
| ::::::: September
6 ::::::: |
|
- * Clinical review:
Paralytic rabies after a two week holiday in India. BMJ
2005;331:501-503 (3 September), doi:10.1136/bmj.331.7515.501 [BBC
News]
- Editorial: Avoiding rabies. BMJ
2005;331:469-470 (3 September), doi:10.1136/bmj.331.7515.469
- Statin treatment within first 24 hours after heart attack cut mortality
by half. American Journal
of Cardiology, [Eurekalert]
- New
England Journal of Medicine Volume 353 September 1, 2005 Number 9
| ::::::: September
2 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles :::::::
|
|
- FDA Approvals: [Medscape review]
- Invader UGT1A1 (molecular
assay) for identifying patients that may be at increased risk of
adverse reactions to the chemotherapy drug irinotecan HCl (Camptosar,
made by Pfizer, Inc.) used in the treatment of colorectal cancer.The
test detects and identifies specific mutations in the gene that
produces UDP-glucuronosyltransferase 1A1 (UGT1A1), an enzyme that
conjugates the active metabolite of irinotecan (SN-38) to form
a glucuronide metabolite.
- SelectSecure Model 3830 (catheter-delivered
lumenless pacing lead) for use with pacemakers, implantable cardioverter
defibrillators, and cardiac resynchronization therapy (CRT) devices,
including CRT pacemakers and CRT defibrillators.
- Duet System (scanning microscope
and image analysis system),use with the UroVysion bladder cancer
kit (made by Vysis, Inc.) to monitor patients for recurrence of
transitional cell bladder cancer.
- MedWatch
Alert: Herceptin Associated With Significant Risk of Cardiotoxicity. [Medscape]
- FDA Safety Labeling Changes: [Medscape]
- Cefuroxime Oral vancomycin is the
treatment of choice for antibiotic-associated pseudomembranous colitis
due to Clostridium difficile that is severe or not relieved by discontinuation
of therapy.
- Zocor (simvastatin) increased risk
of myopathy/rhabdomyolysis associated with use in conjunction with
danazol and potent CYP 3A4 inhibitors.
- Clozaril (clozapine) increased risk
of mortality associated with its use in elderly patients with dementia-related
psychosis.
- FDA Approvals: [Medscape]
- Fluarix (trivalent inactivated split
influenza vaccine) for the prophylaxis of influenza types A and B in
adults, especially those at increased risk of associated complications.
[Medscape report
from CDC news]
- Increlex (mecasermin [rDNA origin]
injection) for the long-term treatment of growth failure in children
with severe primary insulin growth factor 1 (IGF) deficiency or with
growth hormone (GH) gene deletion who have developed neutralizing antibodies
to GH.
- ACTOplus met (pioglitazone plus metformin)
for use as an adjunct to diet and exercise to improve glycemic control
in patients with type 2 diabetes who are already receiving combination
therapy with the individual components or whose diabetes is not adequately
controlled by use of either drug alone.
- Suppression of Aging in Mice by the Hormone Klotho. Science
2005 Published online 25 August. [Methuselah Mice. ScienceNOW ]
- Aberrantly Increased Hydrophobicity Shared by Mutants of Cu,Zn-Superoxide
Dismutase in Familial Amyotrophic Lateral Sclerosis. J.
Biol. Chem. 2005 280: 29771-29779.. Sticky mutant proteins implicated
in Lou Gehrig's disease August 19 issue of the Journal
of Biological Chemistry, an American Society for Biochemistry and Molecular
Biology journal.[Eureklalert]
- Cloning of a human parvovirus by molecular screening of respiratory tract
samples. PNAS
published early 0.1073/pnas.0504666102 [Medscape:
Scientists Identify New Respiratory Virus] Medical
News
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- Assessment of the Emergence of Alzheimer's Disease Following Coronary
Artery Bypass Graft Surgery or Percutaneous Transluminal Coronary. J
Alzheimer's Dis 2005; 7: 319-324.,[Stress and trauma of surgery as
major cause for increased risk of Alzheimer's News
Report].
- Course and prognosis of elbow complaints: a cohort study in general practice. Ann
Rheum Dis 2005; 64: 1331-1336.[Medscape]
- Effect of reproductive factors and postmenopausal hormone use on the
risk of Parkinson disease. Neurology
2005 65: 383-390. [Medscape]